N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-

Details N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]- N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-

1987-10-28

1989-08-01

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564162, C07C15305

Patent

active

048534846

ABSTRACT:
Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amide thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

REFERENCES:
patent: 4317779 (1982-03-01), Crawford
patent: 4439617 (1984-03-01), Sestanj
Walter, Justus Liebigs Ann. Chem., pp. 1584-1597, (1976).

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