N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-[substituted i

Details N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-[substituted i N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-[substituted i

1987-12-23

1989-08-01

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

562427, 562440, C07C14380, A61K 31195

Patent

active

048534129

ABSTRACT:
Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl][substituted imino]methyl]-N-methylglycines and methods for their preparation. The N-methylglycines are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

REFERENCES:
patent: 4391816 (1983-07-01), Sestanj
patent: 4391825 (1983-07-01), Bellini
patent: 4439617 (1984-03-01), Sestanj
patent: 4568693 (1986-02-01), Sestanj
patent: 4734435 (1988-03-01), Ferdinandi
R. Ganellin, J. Med. Chem., 24, 913 (1981).
D. E. Beattie, et al, J. Med. Chem., 20, 718 (1977).

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