N-[[6-(Lower alkoxy)-5-(trifluoromethylthio)-1-naphthalenyl]thio

Details N-[[6-(Lower alkoxy)-5-(trifluoromethylthio)-1-naphthalenyl]thio N-[[6-(Lower alkoxy)-5-(trifluoromethylthio)-1-naphthalenyl]thio

1981-11-13

1983-07-05

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

560 10, 562427, C07C153063, A61K 31165

Patent

active

043918255

ABSTRACT:
Aldose reductase inhibitors of the formula ##STR1## wherein R.sup.1 and R.sup.2 each is lower alkyl, or a therapeutically acceptable salt thereof with an organic or inorganic base, are useful for treating diabetic complications.

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Allinger, "Organic Chemistry", pp. 532-537, (1971).
D. Dvornik et al., Science, 182, 1146, (1973).
M. J. Peterson et al., Metabolism, 28, (Suppl. 1), 456, (1979).
A. Lawson and C. E. Searle, J. Chem. Soc., 1556, (1957).
Chem. Abstrs., 86, 189582f, (1977).
Chem. Abstr., 70, 11306a, (1969).
Chem. Abstr., 61, 4333f, (1964), for E. Cioranescu et al., Rev. Chim. Acad. Rep. Populaire Roumaine, 7 (2), 755, (1962).

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