N-5-protected 2,5-diamino-4,6-dichloropyrimidines and process fo

Details N-5-protected 2,5-diamino-4,6-dichloropyrimidines and process fo N-5-protected 2,5-diamino-4,6-dichloropyrimidines and process fo

1993-01-21

1994-03-15

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544332, C07D23942, C07D23952, C07D23930

Patent

active

052947106

ABSTRACT:
N-5-protected 2,5-diamino-4,6-dichloropyrimidines of general formula: ##STR1## wherein R is an alkoxy group or a trifluorometyl group, are valuable intermediate products for the production of pharmaceutical agents with antiviral properties. The above-mentioned compounds are produced by cyclization of an N protected amino malonic acid ester with guanidine in the presence of an alkali alcoholate and then chlorination of the resulting N-5-protected 4,6-dihydroxy-2,5-diaminopyrimidine.

REFERENCES:
Legraverend et al., Synthesis, (1990), pp. 587 to 599.
Greene, Theodora W., "Protective Groups In Organic Synthesis", John Wiley & Sons (1981).

Affiliated with

Also associated with

Rating

N-5-protected 2,5-diamino-4,6-dichloropyrimidines and process fo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-5-protected 2,5-diamino-4,6-dichloropyrimidines and process fo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-5-protected 2,5-diamino-4,6-dichloropyrimidines and process fo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1536902