N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsu

Details N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsu N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsu

1993-10-21

1995-11-07

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514380, 548241, 548243, 548244, 548245, 546153, 546155, 546159, 546162, 546167, 546172, C07D26106, A61K 3141

Patent

active

054648530

ABSTRACT:
N-(5-isoxazolyl)biphenylsulfonamides and N-(3-isoxazolyl)biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(5-isoxazolyl)biphenylsulfonamides and N-(3-isoxazolyl)biphenylsulfonamides and methods for inhibiting the binding of an endothelin peptide to an endothelin receptor or increasing the activity of endothelin peptides by contacting the receptor with a sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

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