N-(5-aminomethyl-2-oxazolin-2-yl)-N'-phenylureas, compositions a

Details N-(5-aminomethyl-2-oxazolin-2-yl)-N'-phenylureas, compositions a N-(5-aminomethyl-2-oxazolin-2-yl)-N'-phenylureas, compositions a

1983-10-05

1985-02-12

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544137, 544360, 544369, 546146, 546193, 546209, 546281, 548233, 514211, 514212, 514235, 514318, 514325, 514340, 514377, C07D26328, C07D29514, A61K 3142, A61K 31535

Patent

active

044990901

ABSTRACT:
This invention relates to new N-(5-aminomethyl-2-oxazoline-2-yl)-N'-phenylureas, the method for producing them and their application in therapy, particularly in treating convulsions, rhythm troubles, ulcerous disorders or inflammatory or edematous conditions.
The products of this invention have the general formula: ##STR1## wherein R.sub.1 and R.sub.2 independently represent an alkyl radical of C.sub.1 to C.sub.4, or a carbocyclic alkyl radical having 3 or less rings, or a carbocyclic radical having 3 or less rings; R.sub.1 and R.sub.2 can form, with the nitrogen atom to which they are attached, a 4 to 7 member heterocycle containing 1 or 2 nitrogen atoms and 1 or 0 oxygen atoms, said heterocycle can be substituted by R with R being an alkyl radical of C.sub.1 to C.sub.4, allyl, benzyl, pyridyl, phenyl substituted or not by one or more substituents such as halogen, trihalomethyl, alkyl of C.sub.1 to C.sub.4, hydroxy, or alkoxy having a C.sub.1 to C.sub.4 alkyl radical.

REFERENCES:
patent: 3299089 (1967-01-01), Zimmermann et al.

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