N-(4-Pyrazolidinyl)benzamides and their amino precursors

Details N-(4-Pyrazolidinyl)benzamides and their amino precursors N-(4-Pyrazolidinyl)benzamides and their amino precursors

1979-05-22

1980-06-10

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548356, A61K 31415, C07D23104

Patent

active

042073278

ABSTRACT:
N-(4-Pyrazolidinyl)benzamides having the formula ##STR1## and their amino precursors are disclosed wherein R is lower alkyl, lower cycloalkyl or phenyllower-alkyl; R.sup.1 is lower alkyl, lower cycloalkyl, or phenyllower-alkyl; R.sup.2 is hydrogen, lower alkyl or phenyl; R.sup.3 is hydroxy, cyano, nitro, amino, fluoro, chloro, bromo, trifluoromethyl, lower alkyl, lower alkoxy, sulfamoyl or actamido, R.sup.3 can be the same radical or different radicals; n is an integer from zero to three inclusive, and pharmaceutically acceptable acid addition salts thereof. The compounds have anti-emetic and gastric emptying properties.

REFERENCES:
patent: 3342826 (1967-09-01), Miller et al.
patent: 3542804 (1970-11-01), Daniels
patent: 3577440 (1971-05-01), Lunsford et al.
patent: 3963745 (1976-06-01), Cale, Jr. et al.
Iyengar et al., Chem. Abst., 1975, vol. 82, No. 30623r.

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