N-4 modified pyrimidine deoxynucleotides and oligonucleotide pro

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 5, 435 911, 435 912, 536 221, C12Q 168, C12Q 170, C12P 1934, C07H 1900

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055915841

ABSTRACT:
Novel oligonucleotide probes are provided having the structure ##STR1## wherein: R.sup.2 is lower alkyl; R.sup.3 is C.sub.1 -C.sub.12 alkylene containing 0 to 6 linkages selected from the group consisting of --O--, --S-- and --NR.sup.12 -- wherein R.sup.12 is hydrogen or lower alkyl; R.sup.5 is hydrogen or lower alkyl; R.sup.6 is selected from the group consisting of hydrogen, methyl, bromo and iodo; R.sup.7 is C.sub.1 -C.sub.12 alkylene containing 0 to 6 linkages selected from the group consisting of --O--, --S-- and --NR.sup.12 --, and bound to R.sup.8 through an --O--, --S-- or --NR.sup.12 -- moiety; and R.sup.8 is a protecting group that can be removed and replaced, without affecting the remainder of the compound, by reduction with a reducing agent. Methods for using the probes are provided as well.

REFERENCES:
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patent: 5258506 (1993-11-01), Urdea et al.
U.S. Patent Application S.N. 07/813,588 by Mickey S. Urdea, filed Dec. 31, 1991.
U.S. Patent Application S.N. 07/736,445 by Mickey S. Urdea, filed Jul. 24, 1991.
U.S. Patent Application S.N. 07/806,642 by Mickey S. Urdea, filed Dec. 13, 1991.
U.S. Patent Application S.N. 07/559,961 by Mickey S. Urdea, filed Jul. 27, 1990.

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