N-4 modified pyrimidine deoxynucleotides and oligonucleotide pro

Details N-4 modified pyrimidine deoxynucleotides and oligonucleotide pro N-4 modified pyrimidine deoxynucleotides and oligonucleotide pro

1995-04-26

1997-01-07

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 435 911, 435 912, 536 221, C12Q 168, C12Q 170, C12P 1934, C07H 1900

Patent

active

055915841

ABSTRACT:
Novel oligonucleotide probes are provided having the structure ##STR1## wherein: R.sup.2 is lower alkyl; R.sup.3 is C.sub.1 -C.sub.12 alkylene containing 0 to 6 linkages selected from the group consisting of --O--, --S-- and --NR.sup.12 -- wherein R.sup.12 is hydrogen or lower alkyl; R.sup.5 is hydrogen or lower alkyl; R.sup.6 is selected from the group consisting of hydrogen, methyl, bromo and iodo; R.sup.7 is C.sub.1 -C.sub.12 alkylene containing 0 to 6 linkages selected from the group consisting of --O--, --S-- and --NR.sup.12 --, and bound to R.sup.8 through an --O--, --S-- or --NR.sup.12 -- moiety; and R.sup.8 is a protecting group that can be removed and replaced, without affecting the remainder of the compound, by reduction with a reducing agent. Methods for using the probes are provided as well.

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patent: 5124246 (1992-06-01), Urdea et al.
patent: 5258506 (1993-11-01), Urdea et al.
U.S. Patent Application S.N. 07/813,588 by Mickey S. Urdea, filed Dec. 31, 1991.
U.S. Patent Application S.N. 07/736,445 by Mickey S. Urdea, filed Jul. 24, 1991.
U.S. Patent Application S.N. 07/806,642 by Mickey S. Urdea, filed Dec. 13, 1991.
U.S. Patent Application S.N. 07/559,961 by Mickey S. Urdea, filed Jul. 27, 1990.

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