Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-12-02
2000-10-31
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514620, 546330, 546332, 546335, 546337, 564164, C07C23301, C07D21302, A61K 31165, A61K 3144
Patent
active
061403539
ABSTRACT:
N-(4-carbamimidophenylamino) phenylglycineamide derivative compounds having the formula: ##STR1## in which E, g.sup.1, g.sup.2, Q, R and X.sup.1 to X.sup.4 are each as defined in the description, and hydrates or solvates and physiologically acceptable salts thereof can be used as inhibitors of the formation of the coagulation factors Xa, IXa and thrombin induced by the factor VIIa and by the tissue factor. These compounds can be used as medicaments for the treatment and/or prevention of thromboses, apoplexy, cardiac infarction, inflammation and arteriosclerosis or as antitumor agents.
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Ackermann Jean
Grobke Katrin
Ji Yu-Hua
Wallbaum Sabine
Weber Lutz
Davis Zinna Northington
Epstein William H.
Hoffmann-La Roche Inc.
Johnston George W.
Parise John P.
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