N-(4,5-Dihydro-thiazol-2-yl)-3-quinoline-carboxamides having anx

Details N-(4,5-Dihydro-thiazol-2-yl)-3-quinoline-carboxamides having anx N-(4,5-Dihydro-thiazol-2-yl)-3-quinoline-carboxamides having anx

1982-06-09

1984-05-22

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546156, A61K 3147, C07D21556

Patent

active

044501668

ABSTRACT:
Novel N-(4,5-dihydro-thiazol-2-yl)-4-hydroxy-3-quinoline-carboxamides of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R.sub.1 is selected from the group consisting of hydrogen, halogen, linear alkyl of 1 to 4 carbon atoms, branched alkyl of 3 to 5 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF.sub.3 --, CF.sub.3 O--, CF.sub.3 S-- and CH.sub.3 S-- in the 6- or 7-position and their non-toxic, pharmaceutically acceptable acid addition salts having a strong anxiolytic activity and a remarkable affinity for benzodiapines receptors and their preparation.

REFERENCES:
patent: 3992540 (1976-11-01), Clemence et al.
patent: 4107310 (1978-08-01), Allais et al.
patent: 4299831 (1981-11-01), Clemence et al.

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