N-[4-(3-aminopropyl)-aminobutyl]-2-(.omega.-gua nidino-fatty-aci

Details N-[4-(3-aminopropyl)-aminobutyl]-2-(.omega.-gua nidino-fatty-aci N-[4-(3-aminopropyl)-aminobutyl]-2-(.omega.-gua nidino-fatty-aci

1982-09-29

1985-05-21

Waltz, Thomas A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

564157, 564159, 514908, C07C12912, A61K 31155

Patent

active

045185328

ABSTRACT:
N-[4-(3-Aminopropyl)aminobutyl]-2-(.omega.-guanidino-fatty acid-amido)-2-substituted-ethanamides represented by the general formula ##STR1## wherein Y represents --(CH.sub.2 --CH.sub.2 --, --CH.dbd.CH or ##STR2## R represents a hydrogen atom, an alkyl group of 1 to 4 carbon atoms which may have a hydroxyl group as substituent, or a benzyl group, and n is an integer of from 1 to 8, provided that when Y is ##STR3## and n is 4, R represents the groups other than the hydrogen atom; a salt thereof having antitumor activity in experimental animal tumors and a process for the preparation thereof is provided.

REFERENCES:
patent: 3799988 (1974-03-01), Hashimoto et al.
patent: 4416899 (1983-11-01), Umezawa et al.
patent: 4430346 (1984-02-01), Umezawa et al.
Shoji et al., Jour. of Antibiotics 29, 390-393, (1976).
Kido et al., ibid. 33, 791-795, (1980).
Takeuchi et al., ibid. 34, 1619-21, (1981).
Umezawa et al., ibid. 34, 1622-24, (1981).
Kondo et al., ibid. 34, 1625-27, (1981).
Kondo et al., Abstracts, International Conference on Trends in Antibiotic Research, Tokyo, Jun. 14, 15, 1982--p. 15.

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