N-(4-(1-hydroxy-3-(5 ,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6

Details N-(4-(1-hydroxy-3-(5 ,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6 N-(4-(1-hydroxy-3-(5 ,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6

1988-06-29

1989-11-28

Sham, Muykund I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, A61K 31505, C07D42508

Patent

active

048837997

ABSTRACT:
N-[4-{1-Hydroxy-3-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimid in-6-yl)prop-2-yl )benzoyl]-glutamic acid, it salts, and derivatives thereof, have an inhibitory effect on one or more enzymes which utilize folic acid and can be used, alone or in combination, to inhibit the growth of those neoplasms which otherwise depend upon the enzymes so inhibited. The compounds can be prepared through catalytic hydrogenation of a protected derivative of N-[4-{1-hydroxy-3-(2-amino-4-hydroxy-pyrido[2,3-d]pyrimidin-6-yl)prop-2-en -2-yl)benzoyl]glutamic acid and removal of the protecting groups.

REFERENCES:
patent: 4684653 (1987-08-01), Taylor et al.

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