N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and ant

Details N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and ant N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and ant

1985-03-22

1986-02-11

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548450, 514253, 548454, 548468, 514256, 548486, 514333, 514339, 514361, 514362, 514363, 514365, 514372, 514374, 514378, 514397, 514406, 514411, 514418, 544333, 544405, 546256, 546270, 546273, 548127, 548134, 548136, 548181, 548214, 548236, 548247, 548248, 548336, 548374, 548431, A61K 3140, C07D20934

Patent

active

045699429

ABSTRACT:
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also further substituted on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or substituted phenyl group, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and antiinflammatory agents in mammalian subjects. These 2-oxindole-1-carboxamide compounds are of particular value for ameliorating pain in human patients recovering from surgery or trauma, and alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects.
Certain 2-oxindole-1-carboxamide compounds unsubstituted at C-3, but having a substituent on the carboxamide nitrogen, are useful as intermediates to the analgesic and antiinflammatory agents of the invention.

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