N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the pro

Details N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the pro N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the pro

1998-12-24

2000-06-20

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 24, 560 41, 562568, 562571, C07D30734, C07C22928

Patent

active

060779624

ABSTRACT:
This invention relates to the chemical synthesis of N-[N-(3,3-dimethylbutyl)-L-.alpha.-aspartyl]-L-phenylalanine 1-methyl ester using peptide coupling methods. The coupling reaction is conducted by condensation of an activated derivative of novel N-neohexyl-L-aspartic acid with L-phenylalanine or L-phenylalanine methyl ester or by enzymatic coupling of N-neohexyl-L-aspartic acid with L-phenylalanine or L-phenylalanine methyl ester. This invention also relates to novel N-(3,3-dimethylbutyl)-L-aspartic acid, derivatives thereof and the preparation thereof. The activated derivative of N-neohexyl-L-aspartic acid may be an anhydride, mixed anhydride, active ester or an intermediate activated derivative thereof.

REFERENCES:
patent: 5480668 (1996-01-01), Nofre et al.
patent: 5510508 (1996-04-01), Claude et al.
patent: 5728862 (1998-03-01), Prakash
Database CAOLD on STN, Acc. No. CA55:189d, Greenhalgh, `Color Couplers`, Brit. 830,797 (abstract), 1961.

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