N-(23-vinblastinoyl)compounds of 1-aminomethylphosphonic acid us

Details N-(23-vinblastinoyl)compounds of 1-aminomethylphosphonic acid us N-(23-vinblastinoyl)compounds of 1-aminomethylphosphonic acid us

1988-11-23

1990-08-07

Rivers, Diana G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

540478, A61K 31475, C07D51904, C07F 96561

Patent

active

049468332

ABSTRACT:
The invention relates to N-(23-vinblastinoyl)compounds of 1-aminomethylphosphonic acid of general formula I ##STR1## in which: R.sub.1 denotes a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or branched alkylene radical containing from 1 to 6 carbon atoms, an arylalkyl radical having 7 to 10 carbon atoms and capable of bearing a halogen atom as a substituent on the aromatic ring, a hydroxyl radical or an alkyl or alkoxy radical each containing from 1 to 5 carbon atoms, a 2-indolylmethyl radical, a 4-imidzolylmethyl radical or an alkoxycarbonylmethyl radical containing from 3 to 11 carbon atoms,

REFERENCES:
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patent: 3749784 (1973-07-01), Johnson
patent: 4203898 (1980-05-01), Cullinan et al.
patent: 4208414 (1980-06-01), Schinitsky
patent: 4639456 (1987-01-01), Trouet et al.
patent: 4831038 (1989-05-01), Trouet et al.
Drug Evaluations, 6th Edition, American Medical Association, pp. 1180-1183, and 1203-1205 (09/86).
Goodman and Gilman's "The Pharmacological Basis of Therapeutics", Seventh Edition, pp. 1279 (1985).
Proceedings of The American Association for Cancer Research, vol. 30, Mar. 1989, 581, Preclinical Pharmacology and Experimental Therapeutics, 2311.

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