N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic

Details N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic

1981-07-20

1982-09-21

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D20904, C07D20942

Patent

active

043506330

ABSTRACT:
Disclosed herein are 2,3-dihydro-1H-indole-2-carboxylic acids substituted on the nitrogen with 3-mercapto-2-alkyl-1-oxoalkyl, 3-phosphoryl-2-alkyl-1-oxopropyl, or 2-amino-2-alkyl-1-oxoalkyl derivatives which act as inhibitors of angiotensin converting enzyme and as antihypertensive agents. The compounds of the invention (excluding disclosed intermediates) have the general formula: ##STR1## wherein: n is 1 or 0;

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