Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1975-03-03
1977-04-19
Coughlan, Jr., Paul M.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2602564C, 424251, C07D23942
Patent
active
040187705
ABSTRACT:
Compounds useful as anti-allergic agents are 2-Q-4-[XZC=C(R)NH]-5-R.sub.1 -6-R.sub.2 -pyrimidines (I), where Q is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents or N-oxide thereof, R is hydrogen or lower-alkyl, R.sub.1 is hydrogen, lower-alkyl or cyano, R.sub.2 is hydrogen, lower-alkyl, hydroxy or halo, X and Z are the same or different and are each selected from lower-carbalkoxy, lower-alkanoyl, carbamyl and cyano, or ##STR1## where R.sub.3 and R.sub.4 are each lower-alkyl, or X is hydrogen, are prepared by reacting 4-amino-2-Q-5-R.sub.1 -6-R.sub.2 -pyrimidine (II where Q' is amino) with R'O-C-(R)=CXZ (III). Preparations of II are given. Also shown as intermediates and/or anti-allergic agents are 4-(AcNH)-2-Q-5-R.sub.1 -6-R.sub.2 -pyrimidines (IV) and 4-(R.sub.5 R.sub.6 N)-2-Q-5-R.sub.1 -6-R.sub.2 -pyrimidines (V) where Ac is lower-alkanoyl or lower-carbalkoxy, R.sub.5 is hydrogen, lower-alkyl or lower-hydroxyalkyl, and R.sub.6 is lower-alkyl or lower-hydroxyalkyl.
REFERENCES:
patent: 3673184 (1972-06-01), Minami et al.
Lesher George Y.
Singh Baldev
Bair Robert K.
Coughlan, Jr. Paul M.
Sterling Drug Inc.
Wyatt B. Woodrow
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