N-(2-oxpyrrolidin-1-yl-)acetyl)piperazine derivatives and drug f

Details N-(2-oxpyrrolidin-1-yl-)acetyl)piperazine derivatives and drug f N-(2-oxpyrrolidin-1-yl-)acetyl)piperazine derivatives and drug f

1988-07-15

1990-02-27

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544360, 544372, A61K 31495, C07D40306, C07D40114, C07D40314

Patent

active

049046632

ABSTRACT:
A compound of the formula: ##STR1## (wherein R is --SO.sub.2 R.sup.1 or --CONHR.sup.2 ; R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.8 -C.sub.12 phenylalkenyl, amino, dimethylamino, optionally substituted C.sub.8 -C.sub.12 aryl, or 5- or 6-membered heterocyclic group including at least one hetero atom selected from the group consisting of N, S, and O; R.sup.2 is amino, C.sub.1 -C.sub.8 alkylamino, C.sub.1 -C.sub.8 alkyl, or optionally substituted C.sub.8 -C.sub.12 aryl) or its pharmaceutically acceptable acid-addition salt, being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.

REFERENCES:
patent: 4221789 (1980-09-01), Rodriguez et al.
patent: 4372960 (1983-02-01), L'Italien
patent: 4476308 (1984-10-01), Aschwanden et al.
patent: 4668687 (1987-05-01), Yevich et al.
Vedrilla, Chemical Abstracts, vol. 99, No. 88230 (1983).
Yevich et al., Chemical Abstracts, vol. 105, No. 172506 (1986).
Veda et al., Chemical Abstracts, vol. 106, No. 67300 (1987).

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