N[(2-Naphthalenyl)thioxomethyl]glycine derivatives

Details N[(2-Naphthalenyl)thioxomethyl]glycine derivatives N[(2-Naphthalenyl)thioxomethyl]glycine derivatives

1981-11-13

1984-05-08

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

560 10, 560 56, 560100, 562427, C07C15305, A61K 31195

Patent

active

044474520

ABSTRACT:
Herein disclosed are N-[(2-naphthalenyl)thioxomethyl]glycine derivatives of the formula ##STR1## wherein R.sup.1 is lower alkyl and R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halo or trifluoromethyl. The derivatives have aldose reductase inhibiting activity and are useful for treating diabetic complications.

REFERENCES:
patent: 3489793 (1970-01-01), Bertelli
patent: 3619196 (1971-11-01), Iwama
patent: 3821383 (1974-06-01), Sestanj et al.
Allinger, "Organic Chemistry", pp. 532-537 (1971).
D. Dvornik et al., Science, 182, 1146(1973).
M. J. Peterson et al., Metabolism, 28 (suppl. 1), 456 (1979).
A. Lawson and C. E. Searle, J. Chem. Soc., 1556 (1957).
V. I. Cohen et al., Chem. Abstr., 86, 189582f (1977).
J. Voss and W. Walter, Chem. Abstr., 70, 11306a (1969).
Chem. Abstr., 61, 4333f (1964).
Chem. Abstr., 73, 30644n (1970).

Affiliated with

Also associated with

Rating

N[(2-Naphthalenyl)thioxomethyl]glycine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N[(2-Naphthalenyl)thioxomethyl]glycine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N[(2-Naphthalenyl)thioxomethyl]glycine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1602389