N-(2-imidazolidinylidene)-5H-dibenzo[a,d]cyclohepten-5-amine com

Details N-(2-imidazolidinylidene)-5H-dibenzo[a,d]cyclohepten-5-amine com N-(2-imidazolidinylidene)-5H-dibenzo[a,d]cyclohepten-5-amine com

1984-01-19

1986-05-20

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548315, C07D40330, A61K 31415

Patent

active

045902020

ABSTRACT:
N-(2-Imidazolidinylidene)-5H-dibenzo[a,d]cyclohepten-5-amine compounds are disclosed. The compounds have the property of inhibiting calcium induced contraction of smooth muscle. Certain of the compounds have properties of .alpha..sub.2 -adrenergic antagonists and others of .alpha..sub.2 -adrenergic agonists.

REFERENCES:
patent: 2985660 (1961-05-01), Judd et al.
patent: 3014911 (1961-12-01), Engelhardt
J. Med. Chem. 8, pp. 829-835 (1965) Engelhardt et al.
Merck Index vol. 10, pp. 398-399 (1983).
Lowe, et al., Br. J. Pharmac., 74, pp. 651-663, (1981).

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