N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxam

Details N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxam N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxam

1991-06-24

1992-08-25

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 69, A61K 3148, C07D45704

Patent

active

051419440

ABSTRACT:
This invention provides N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides useful for blocking 5HT.sub.2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating sexual dysfunction, hypertension, migraine, vasospasm, thrombosis, ischemia, depression, anxiety, sleep disorders and appetite disorders with a compound of the invention.

REFERENCES:
patent: 3580916 (1971-05-01), Garbrecht
patent: 4713384 (1987-12-01), Cohen et al.
patent: 4810710 (1989-03-01), Cohen et al.
patent: 4902691 (1990-02-01), Cohen et al.
patent: 4931447 (1990-06-01), Garbrecht et al.
patent: 5043341 (1991-08-01), Cohen et al.

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