Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-03-15
2009-11-24
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S295000
Reexamination Certificate
active
07622473
ABSTRACT:
The present invention is directed to metabolites of ′N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, the compound of formula (I), pharmaceutical compositions thereof, and to methods of using the metabolites and the pharmaceutical compositions in the treatment of oncological and immunological disorders.
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http://www.encyclopedia.com/doc/1E1-metabolit.html; last accessed on Aug. 25, 2008.
Neil P. Shah et al., “Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor”, Science, vol. 305, Jul. 16, 2004, pp. 399-401.
Louis J. Lombardo et al., “Discovery of N-(2-Chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays”, J. Med. Chem., vol. 47, 2004, pp. 6658-6661.
Arora Vinod Kumar
Christopher Lisa Joy
Cui Donghui
Li Wenying
Bristol--Myers Squibb Company
Murray Jeffrey H
VanAtten Mary K.
Wilson James O
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