N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-n&#x203...

Details N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-n&#x203... N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-n&#x203...

2007-01-23

2007-01-23

Chang, Celia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S312000

Reexamination Certificate

active

10532104

ABSTRACT:
The present invention provides a crystal of a pharmaceutically acceptable salt of N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(5-methyl-3-isoxazolyl) urea. This crystal of salt is usable for the therapy of a disease selected from the group consisting of tumors, diabetic retinopathy, chronic rheumatism, psoriasis, atherosclerosis, Kaposi's sarcoma, and exudation type age-related maculopathy, and has characteristics suitable for applications of oral pharmaceutical preparations.

REFERENCES:
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patent: WO 2004/060373 (2004-07-01), None
Matsunage et al. “N- . . . ” CA 140:363009 (2004).
Brittain “Polymorphism in pharmaceutical solids” Marcel Dekker, p. 27-31 (1999).

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