N-(2-Arylethyl) benzylamines as antagonists of the 5-HT 6...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S654000, C548S503000, C564S503000

Reexamination Certificate

active

10472741

ABSTRACT:
The present invention provides compounds of formula Ipharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are antagonists of the 5-HT6receptor. The present invention further provides a method of treating disorders associated with 5-HT6receptors, including schizophrenia, anxiety, Alzheimer's disease, and cognitive disorders selected from the group consisting of age-related cognitive decline, mild cognitive impairment, and dementia, comprising: administering to a patient in need thereof an effective amount of a compound of formula I.

REFERENCES:
patent: 6187805 (2001-02-01), McAllister et al.
patent: 6750348 (2004-06-01), Bridger et al.
patent: 2 085 006 (1982-04-01), None
patent: WO 93/11761 (1993-06-01), None
patent: WO 99/16746 (1999-04-01), None
patent: WO 00/34242 (2000-06-01), None
patent: WO-0042045 (2000-07-01), None
Database Crossfire Beilstein Online! Institut zur Forderung der Chemischen Wissenschaften, Frankfurt am Main DE; (3-ethoxy-benzyl)-(3-ethoxy-phenethyl)-amine), Database accession No. 3365863: XP002209140.
Tsai et al. “N1-(Benzenesulfonyl)tryptamines as Novel 5-HT6 Antagonists” Bioorganic & Medicinal Chemistry Letters 2000, 2295-2299.
Bromidge et al. “Phenyl Benzenesulfonamides are Novel and Selective 5-HT6 Antagonists: Identification of . . . ” Bioorganic & Medicinal Chemistry Letters, 2001, 55-58.
Isaac et al. “6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-Bicyclopiperidinyl-1-arylsulfonylindoles Derivatives as Novel, Potent, and Selective 5-HT6 Receptor Antagonists” Bioorganic & Medicinal Chemistry Letters 2000, 1719-1721.
Ide et al. “Pharmacologically Active Compounds from Alkoxy-B-phenylethylamines” Journal of the American Chemical Society 1937, 726-731.
Database Crossfire Beilstein Online! Beilstein Institut zur Forderung der Chemischen Wissenschaften, Frankfurt am Main, DE; (3-ethoxy-benzyl)-(4-ethoxy-phenethyl)-amine), IDE, BUCK: Database accession No. 3365864; XP002209139.
Database Crossfire Beilstein Online! Beilstein Institut zur Forderung der Chemischen Wissenschaften, Frankfurt am Main, DE; (3-ethoxy-benzyl)-(3-ethoxy-phenethyl)-amine), Database accession No. 3365863; XP002209140.
Database Crossfire Beilstein Online! Beilstein Institut zur Forderung der Chemischen Wissenschaften, Frankfurt am Main, DE; (3-ethoxy-benzyl)-(2-ethoxy-henethyl)-amine), IDE, BUCK: Database accession No. 3380345; XP002209141.
Barton, et al., “886. Phenol Oxidation and Biosynthesis. Part VI. The Biogenesis of Amaryllidaceae Alkaloids,” Barton, Kirby, Taylor and Thomas, pp. 4545-4558 (1963).
Vinogradova, et al., “Synthesis Based on b-Phenylethylamines. IV. Synthesis and Antiarrhythmic Activity of Substituted Phenylalkylamines and N-Benzyltetrahydroisoquinolines,” vol. 29, No. 3, pp. 259-414 (1993).
Vinogradova, et al., “Syntheses Based on b-Ethylamines. VIII. Synthesis of Substituted 2-Benzyltetrahydroisoquinolines and Their Influence on Bile Secretion,” vol. 30, No. 3, pp. 368-370 (1994).
ACS Chemcats 2000:1020106, Order No. STOCK1S-08349, CAS Registry No. 302795-49-9.
Bos et al., “5-HT6 receptor antagonists: lead optimization and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides,”Eur J. Med. Chem.,vol. 36, pp. 165-178 (2001).
Bourson et al., “Determination of the Role of the 5-ht6 Receptor in the Rat Brain: A Study using Antisense Oligonucleotides,”J. of Pharm. And Experimental Therapeutics,vol. 274, No. 1, pp. 173-180 (1995).
Meneses, Alfredo, “Effects of the 5-HT6 receptor antagonist Ro 04-6790 on learning consolidation,”Behavioral Brain Research,vol. 118, pp. 107-110 (2001).
Rogers et al., “5-HT6 receptor antagonists enhance retention of a water maze task in the rat,”Psychopharmacology,vol. 158, pp. 114-119 (2001).

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