N-(2-Aminocyclopentyl)-N-acylanilides as CNS anti-depressants

Details N-(2-Aminocyclopentyl)-N-acylanilides as CNS anti-depressants N-(2-Aminocyclopentyl)-N-acylanilides as CNS anti-depressants

1978-05-15

1979-06-26

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260455A, 260551S, 260557R, 260561B, 260561N, 260562A, 260562R, 424301, 424324, 560 27, 424226, 424267, 424274, C07C10334, C07C10344

Patent

active

041593405

ABSTRACT:
N-(2-Aminocyclopentyl)-N-acylanilides and their 2-N-oxides of the formula ##STR1## e.g., trans-3,4-dichloro-N-[2-(N-allylamino)cyclopentyl]propionanilide, and their pharmacologically acceptable salts have been found to possess potent Central Nervous System anti-depressant properties. Many of them are new.
These compounds are promising anti-depressant drugs which are characterized by a better therapeutic ratio than imipramine, and long acting activity which may allow longer durations between administrations, e.g., once a day. Pharmaceutical compositions containing these compounds and a process for treating conditions of depression with these compositions are disclosed.

REFERENCES:
patent: 3150185 (1964-09-01), Luvisi
patent: 3510495 (1970-05-01), Szmuszkovicz
Stoll e.a. Helvetia Chim. Acta 34(1951), pp. 1937-1943.
Loevenich e.a. Chem. Berichte 62, p. 3094.
Lewis et al., J. Chem. Soc., Perkins Trans. (1972), pp. 2521-2524.
Lewis et al., J. Pharm. Sci. 63(1974), pp. 1951-1953.

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