N-(2-Aminocyclopentyl) alkanoylanilides

Details N-(2-Aminocyclopentyl) alkanoylanilides N-(2-Aminocyclopentyl) alkanoylanilides

1978-02-21

1979-05-29

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

2603264, 424267, 546231, 546234, 546232, A61K 3140, A61K 31445, C07D20712, C07D21106

Patent

active

041567331

ABSTRACT:
N-(2-Aminocyclopentyl)N-alkanoylanilides and their 2-N-oxides of the formula ##STR1## e.g., trans-3,4-dichloro-N-[2-(dimethylamino)cyclopentyl]propionanilide, and their pharmacologically acceptable salts, have been found to possess potent Central Nervous System anti-depressant properties. Many of them are new.
These compounds are promising anti-depressant drugs which are characterized by a better therapeutic ratio than imipramine, and long acting activity which may allow longer durations between administrations, e.g., once a day. Pharmaceutical compositions containing these compounds and a process for treating conditions of depression with these compositions are disclosed.

REFERENCES:
patent: 3510492 (1970-05-01), Szmuszkovicz

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