N-(2-Aminocyclopentyl)acylanilides and treating depression

Details N-(2-Aminocyclopentyl)acylanilides and treating depression N-(2-Aminocyclopentyl)acylanilides and treating depression

1978-02-21

1979-06-05

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2603264, 424274, 546 18, 546192, 546229, 546231, 546234, 546232, 546240, 546236, A61K 3140, A61K 31445, C07D20712, C07D21106

Patent

active

041573986

ABSTRACT:
N-(2-Aminocyclopentyl)N-alkanoylanilides and their 2-N-oxides of the formula ##STR1## e.g., trans-3,4-dichloro-N-[2-(dimethylamino)cyclopentyl]propionanilide, and their pharmacologically acceptable salts, have been found to possess potent Central Nervous System anti-depressant properties. Many of them are new.
These compounds are promising anti-depressant drugs which are characterized by a better therapeutic ratio than imipramine, and long acting activity which may allow longer durations between administrations, e.g., once a day. Pharmaceutical compositions containing these compounds and a process for treating conditions of depression with these compositions are disclosed.

REFERENCES:
patent: 3510492 (1970-05-01), Szmuszkovicz

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