N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of d

Details N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of d N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of d

1978-03-13

1979-05-22

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260562R, 424226, 424267, 424274, A61K 31165, C07C10310, C07C10332

Patent

active

041560140

ABSTRACT:
N-(2-aminocycloheptyl)N-alkanoylanilides and their 2-N-oxides of the formula ##STR1## e.g., trans-3,4-dichloro-N-[2-(dimethylamino)cycloheptyl]propionanilide, and their pharmacologically acceptable salts, have been found to possess potent Central Nervous System antidepressant properties. Many of them are new.
These compounds are promising antidepressant drugs which are characterized by lower toxicity than imipramine, and long acting activity which may allow longer durations between administrations, e.g., once a day. Pharmaceutical compositions containing these compounds and a process for treating conditions of depression with these compositions are disclosed.

REFERENCES:
patent: 3510492 (1970-05-01), Szmuszkovicz

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