N-(2-aminocycloheptyl)acylanilides

Details N-(2-aminocycloheptyl)acylanilides N-(2-aminocycloheptyl)acylanilides

1978-05-30

1979-10-30

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260455A, 260562A, 260562R, 260557R, 424311, 560 27, 2603264, 2603265S, 26032681, 546234, A61K 3122, A61K 31165, C07C15503, C07C15707

Patent

active

041728980

ABSTRACT:
N-(2-aminocycloheptyl)-N-alkanoylanilides and their 2-N-oxides of the formula ##STR1## e.g., trans-3,4-dichloro-N-[2-(dimethylamino)cycloheptyl]acrylanilide, and their pharmacologically acceptable salts, have been found to possess potent Central Nervous System anti-depressant properties. Many of them are new.
These compounds are promising anti-depressant drugs which are characterized by lower toxicity than imipramine, and long acting activity which may allow longer durations between administrations, e.g., once a day. Pharmaceutical compositions containing these compounds and a process for treating conditions of depression with these compositions are disclosed.

REFERENCES:
patent: 3510492 (1970-05-01), Szmuszkovicz

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