N-(((2,6-disubstituted)phenyl)-N-diarylalkyl)ureas as antihyperl

Details N-(((2,6-disubstituted)phenyl)-N-diarylalkyl)ureas as antihyperl N-(((2,6-disubstituted)phenyl)-N-diarylalkyl)ureas as antihyperl

1988-03-30

1992-05-26

Elmore, Carolyn

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514336, 514342, 514345, 514353, 514357, 514444, 514445, 514447, 514438, 514585, 514586, 514587, 514596, 514598, 514824, 564 27, 564 28, 564 29, 564 26, 564 48, 564 52, 546261, 546265, 546284, 546291, C07C27534, C07C27528, A61K 3117

Patent

active

051168480

ABSTRACT:
Certain N-2,6-dialkyl- or N-2,6-dialkoxphenyl-N'-diarylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis with urea and thiourea compounds.

REFERENCES:
patent: 2911393 (1959-11-01), Brooks et al.
patent: 3028391 (1962-04-01), Rorig
patent: 4387105 (1983-06-01), DeVries et al.
patent: 4387106 (1983-06-01), DeVries et al.
patent: 4397868 (1983-08-01), DeVries
patent: 4410697 (1983-10-01), Torok et al.
patent: 4473579 (1984-09-01), DeVries et al.
patent: 4623662 (1986-11-01), DeVries

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