N-(1H-tetrazol-5-yl-alkylphenyl)polyfluoroalkanamides

Details N-(1H-tetrazol-5-yl-alkylphenyl)polyfluoroalkanamides N-(1H-tetrazol-5-yl-alkylphenyl)polyfluoroalkanamides

1987-06-15

1988-08-16

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514884, 514866, C07D25704

Patent

active

047646233

ABSTRACT:
Compounds of the formula: ##STR1## where R is hydrogen or A--(CF.sub.2).sub.m --CH.sub.2 --; A is --F or --H; n is an integer from 1 to 10, inclusive; m is an integer from 0 to 9, inclusive; p is an integer from 0 to 4, inclusive; and Y is hydrogen, halo, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or hydroxy; or a pharmaceutically acceptable salt thereof. The compounds are useful as anti-hyperglycemic and anti-hyperinsulinemic agents.

REFERENCES:
patent: 3894033 (1975-07-01), Holland
patent: 4216330 (1980-08-01), Shepherd
Stout, Metabolism 34, 7 (1985).
Fujita et al., Diabetes 32, 804 (1983).
Sohda et al., Chem. Pharm. Bull. 32(6) 2267 (1984).

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