Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-10-08
1995-03-28
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546284, C07D40908, A61K 3144
Patent
active
054017556
ABSTRACT:
Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of an N-(1-thienylcycloalkyl)alkenylamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 are defined in specification.
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Contreras Patricia C.
Gray Nancy M.
Jacobson Arthur E.
Mattson Mariena V.
O'Donohue Thomas L.
G. D. Searle & Co.
Keane J. Timothy
National Institutes of Health
Rotman Alan L.
Ungemach Frank s.
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