Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2006-10-24
2006-10-24
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C514S617000
Reexamination Certificate
active
07126027
ABSTRACT:
The present invention relates to N-[(1-dimethylaminocycloalkyl)methyl]benzamide derivatives having the general formula Iwherein n is 0, 1, 2 or 3; R1and R2are independently H, (C1-4)alkyl or (C1-4)alkyloxy;R3is (C3-8)alkyl, (C4-7)cycloalkyl, (C4-7)cycloalkyl (C1-3)alkyl, (C6-12)aryl(C1-3)alkyl (wherein the aryl moiety is optionally substituted with 1–3 substituents selected from (C1-4)alkyl, (C1-4)alkyloxy, halogen, trifluoromethyl and methoxycarbonyl), or (C4-9)heteroaryl(C1-3)alkyl; or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, and to the use of these N-[(1-dimethylaminocycloalkyl)methyl]benzamide derivatives in the treatment of disorders or conditions which are responsive to inhibition of the GlyT-2 transporter, such as muscle spasticity, epilepsy and, particularly, acute, chronic and neuropathic pain.
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Morphy John Richard
Rankovoc Zoran
Akzo Nobel N.V.
Hess Susan
Kumar Shailendra
Milstead Mark W.
Vickrey David H.
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