N-1-alkyl-2,5-Di(trialkyl silyl) pyrrolidines

Details N-1-alkyl-2,5-Di(trialkyl silyl) pyrrolidines N-1-alkyl-2,5-Di(trialkyl silyl) pyrrolidines

1995-12-18

1997-08-05

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07F 702

Patent

active

056544391

ABSTRACT:
A novel 6-chloro-3-vinyl-pyridine of formula ##STR1## where X represents --H, --SO.sub.2 Ph, --CO.sub.2 Et, --COCH.sub.3 and --CHO; which is used for the synthesis of Epibatidine of formula ##STR2## by reacting said 6-chloro-3-vinyl pyridine with N-1-alkyl-2,5-di(trialkyl silyl) pyrrolidine of formula ##STR3## to obtain N-alkyl Epibatidine which is hydrogenated to obtain the Epibatidine.

REFERENCES:
Pandey, G. "Efficient Generation . . . " Tetrahedron Letters, vol. 34, No. 45, pp. 7301-7304, 1993.
Pandey, G. "An Expeditious Synthesis . . . " Tetrahedron Letters, vol. 35, No. 40, pp. 7439-7442, 1994.
Broka, C. "Total Synthesis . . . " CA 119(23) : 250211C (1993).
Corey, E.J. et al. "Stereo-controlled total," CA 120 (7); 77489 v 1993.

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