Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-04-04
2010-12-28
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S363000, C546S268700, C548S138000
Reexamination Certificate
active
07858647
ABSTRACT:
The present invention comprises N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, their physiologically acceptable salts and functional derivatives that exhibit peroxisome proliferator activated receptor (PPAR) PPARdelta and PPARgamma agonist activity. The structure of the compounds of the invention are defined by Formula I below,And the isomers thereof wherein the various substituents are defined herein, including their physiologically acceptable salts. Processes for the compounds preparation are also disclosed. The compounds are suitable for the treatment of fatty acid metabolism and glucose utilization disorders, disorders relating to insulin resistance are involved as well as demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.
REFERENCES:
patent: 1277729 (2003-01-01), None
patent: WO 2005/005421 (2005-01-01), None
Khlaponina et al., Synthesis and Hypoglycemic Activity of 4-(Beta-Acylamidoethyl) Benzenesulfamides, Pharmaceutical Chemistry Journal, vol. 21, No. 8, pp. 588-591 (1987).
Khlaponina, L.N., et. al., Synthesis and Hypoglycemic Activity of 4-(Beta-Acylamidoethyl) Benzenesulfonamides, Pharmaceutical Chemistry Journal, vol. 21, No. 8, pp. 588-591, (1987).
Falk Eugen
Glien Maike
Keil Stefanie
Matter Hans
Schaefer Hans-Ludwig
Lin Jiang
Otton Alicia L
Sanofi-Aventis
Shameem Golam M. M.
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