MYPPPY variants of CTL A4 and uses thereof

Details MYPPPY variants of CTL A4 and uses thereof MYPPPY variants of CTL A4 and uses thereof

1995-07-21

1998-06-30

Spector, Lorraine M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 4351721, 4352523, 4353201, 4351921, 435358, 435361, 435362, 530350, 5303871, 5303873, 53038875, 536 235, C12N 1512

Patent

active

057732531

ABSTRACT:
The invention provides CTLA4 mutant molecules as ligands for the B7 antigen. Methods are provided for expressing CTLA4 mutant molecules as soluble, functional molecules, for preparing CTLA4 mutant fusion proteins, and for using these soluble molecules to regulate T cell interactions and immune responses mediated by such interactions.

REFERENCES:
patent: 4399216 (1983-08-01), Axel
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4853332 (1989-08-01), Mark et al.
Dariavach et al., Eur.J.Immunol. 18:1901-1905, 1988.
Aruffo et al, Proc.Natl.Acad.Sci. USA 84:8573-8577, 1987.
Linsley et al., "Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule" Science 257:792-795 (1992).
Lenschow et al. "Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4Ig", Science 257:789-792 (1992).
Peach et al., "Complementarity Determining Region 1 (CDR1)-and CDR3-analogous Regions in CTLA-4 and CD28 Determine the Binding to B7-1", J. Ex. Med., 180:2049-2058 (1994).
Janeway, "Approaching the Asympote? Evolution and Revolution in Immunology", Cold Spring Harbor Symp. Quant. Biol. LIV:1-13 (1989).
Shaw and Shimuzu, "Two Molecular Pathways of Human T Cell Adhersion; Establishment of Receptor-Ligand Relationship ", Current Opinion in Immunology, Eds. Kindt and Long, 1:92-97 (1988).
Hemler, "Adhesive Protein receptors on Hematopoietic Cells", Immunology Today 9:109-113 (1988).
Kakiuchi et al., B Cells as Antigen-Presenting Cells: The Requirement for B Cell Activation:, J. Immunol. 131:109-114 (1983).
Krieger et al., Antigen Presentation by Splenic B Cells: Resting B Cells are Ineffective, Whereas Activated B Cells are Effective Accessory Cells for T Cell Responses:, J. Immunol. 135:2937-2945 (1985).
McKenzie "Alloantigen Presentation by B Cells--Requirement for IL-1 and IL-6", J. Immunol. 141:2907-2911 (1988).
Hawrylowicz and Unanue, "Regulation of Antigen-Presentation-I IFN-.gamma. Induces Antigen-Presenting Properties on B Cells", J. Immunol. 141:4083-4988 (1988).
Springer et al., "The Lymphocyte Function-Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System", A Rev. Immunol. 5:223-252 (1987).
Dinarello and Mier, Current Concepts--Lymphokines:, New Engl. Jour. Med. 317:940-945 (1987).
Weiss et al., "The Role of the T3/Antigen Receptor Complex in T-Cell Activation", Ann. Rev. Immunol. 4:593-619 (1986).
McMichael, Ed., "Non-lineage, LFA-1 Family, and Leucocyte Common Antigens: New and Previously Defined Clusters", Leukocyte Typing III, Oxford Univ. Press, Oxford UK (1987).
Moingeon et al., "CD2-mediated Adhesion Facilitates T Lymphocyte Antigen Recognition Function", Nature 339:312-314 (1988).
Makgoba et al., ICAM-1 A Ligand for LFA-1-Dependent Adhesion of B, T and Myeloid Cells, Nature 331:86-88 (1988).
Staunton et al., "Functional Clonging of ICAM-2, A Cell Adhesion Ligand for LFA-1 Homologous to ICAM-1", Nature 339:61-64 (1989).
Norment et al., "Cell-Cell Adhesion Mediated by CD8 and MHC Class I Molecules", Nature 336:79-81 (1988).
Doyle and Strominger, "Interaction Between CD4 and Class II MHC Molecules Mediates Cell Adhesion", Nature 330:256-259 (1987).
Stoolman, "Adhesion Molecules Controlling Lymphocyte Migration", Cell 56:907-910 (1989).
Brescher and Cohn, "A Theory of Self-Nonself Discrimination", Science 169:1042-1049 (1970).
Freeman et al., "B7, A New Member of the Ig Superfamily with Unique Expression on Activated and Neoplastic B Cells", J. Immunol. 143(8):2714-2722 (1989).
Freedman et al., "B7, A B Cell-Restricted Antigen that Identifies Preactivated B Cells", J. Immunol. 138:3260-3267 (1987).
Clark et al., "Polypeptides on Human B Lymphocytes Associated with Cell Activation", Human Immunol. 16:100-113 (1986).
Yokochi et al., B Lymphoblast Antigen (BB-1) Expressed on Epstein-Barr Virus-Activated B Cells Blasts, B Lymphoblastoid Cell Lines, and Burkitt's Lymphomas:, J. Immunol. 128:823-827 (1981).
Weiss, "Structure and Function of the T Cell Antigen Receptor", J. Clin. Invest. 86:1015-1022 (1990).
Allen, "Antigen Processing at the Molecular Level", Immunol. Today 8:270-273 (1987).
Schwartz, "A Cell Culture Model for T Lymphocyte Clonal Anergy", Science 248:1349-1356 (1990).
Weaver and Unanue, "The Costimulatory Function of Antigen-Presenting Cells", Immunol. Today 11:49-55 (1990).
Aruffo and Seed, "Molecular Cloning of a CD28 cDNA by a high-Efficiency COS Cell Expression System", Proc. Natl. Acad. Sci. 84:8573-8577 (1987).
Damle et al., Alloantigen -Specific Cytotoxic and Suppressor T Lymphocytes are Drived from Phenotypically Distinct Precursors:, J. Immunol. 131:2296-2300 (1983).
June et al., "T-Cell Proliferation Involving the CD28 Pathway is Associated with Cyclosporine-Resistant Interleukin 2 Gene Expression", Mol. Cell. Biol. 7:4472-4481 (1987).
Thompson et al., "CD28 Activation Pathway Regulates the Production of Multiple T-Cell-Derived Lymphokines/Cytokines", Proc. Natl. Acad. Sci. 86:1333-1337 (1989).
Lindsten et al., "Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway", Science 244:339-343 (1989).
Damle et al., "Monoclonal Antibody Analysis of Human T Lymphocyte Subpopulations Exhibiting Autologous Mixed Lymphocyte Reaction", Proc. Natl. Acad. Sci. 78:5096-5098 (1981).
Lesslauer et al., "T90/44 (9.3 Antigen). A Cell Surface Molecule with a Function in Human T Cell Activation", Eur. J. Immunol. 16:1289-1296 (1986).
Linsley et al., "T-Cell Antigen CD28 Mediates Adhesion with B Cells by Interacting with Activation Antigen B7/BB-1", Proc. Natl. Acad. Sci. USA 87:5031-5035 (1990).
Linsley et al., "Binding of the B Cell Activation Antigen B7 to CD28 Costimulates T Cell Proliferation and Interleukin 2 mRNA Accumulation", J. Exp. Med. 173-721-730 (1991).
Kohno et al., "CD28 Molecule as a Receptor-like Function for Accessory Signals in Cell-Mediated Augmentation of IL-2 Production", Cell. Immunol. 131:1-10 (1990).
Brunet et al., "A New Member of the Immunoglobulin Superfamily--CTLA-4", Nature 328:267-270 (1987).
Brunet et al., "A Differential Molecular Biology Search for Genes Preferentially Expressed in Functional T Lymphocytes: The CTLA Genes", Immunol. Rev. 103:21-36 (1988).
Dariavach et al., "Human IG Superfamily CTLA-4 Gene: Chromosomal Localizaiton and Identity of Protein Sequence Between Murine and Human CTLA-4 Cytoplasmic Domains", Eur. J. Immunol. 18:1901-1905 (1988).
Lafage-Pochitaloff et al., "Human CD28 and CTLA-4 and Ig Superfamily genes are Located on Chromosome 2 at bands q33-q34", Immunogenetics 31:198-201 (1990).
Capon et al., "Designing CD4 Immunoadhesions for AIDS Therapy", Nature 337:525-531 (1989).
Malik et al, "Molecular Cloning, Sequence Analysis, and Functional Expression of a Novel Growth Regulator, Oncostatin M", Molec. and Cell. Biol. 9:2847-2853 (1989).
Storb, "Marrow Transplantation for Severe Aplastic Anemia: Methotrexate Alone Compared wtih a Combination of Methotrexate and Cyclosporine for Prevention of Acute Graft-Versus-Host Disease", Blood 56:119-125 (1986).
Storb and Thomas, "Graft-Versus-Host Disease in Dog and Man: The Seattle Experience", Immunol. Rev. 88:215-238 (1985).
Aruffo et al., "CD44 is the Principal Cell Surface Receptor for Hyaluronate", Cell 61:1303-1313 (1990).
Seed and Aruffo, "Molecular Clonging of the CD2 Antigen, the T-Cell Erythrocyte Receptor, by a Rapid Immunoselection Procedure", Proc. Natl. Acad. Sci. 84:3365-3369 (1987).
Aruffo and Seed, "Molecular Cloning of Two CD7 (T-Cell Leukemia Antigen) cDNAs by a COS Cell Expression System", EMBO Hour. 6:3313-3316 (1987).
Ledbetter et al., "Crosslinking of Surface Antigens Causes Mobilization of Intracellular Ionized Calcium in T Lymphocytes", Proc. Natl. Acad. Sci. 84:1384-1388 (1987).
Ledbetter et al., "CD28 Ligation in T-Cell Activation: Evidence for Two Signal Transduction Pathways", Blood 75:1531-1539 (1990).
Damle et al., "Immunoregulatory T Lymphocytes in Man", J. Immunol. 139:1501-1508 (1987).
Wysocki and Sato, "Panning for Lymphocytes: A Method for Cell Selection", Proc. Natl. Acad. Sci. 75:2844-2848 (1978).
Damle et

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