Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2008-05-06
2008-05-06
Qian, Celine (Department: 1636)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C514S002600
Reexamination Certificate
active
07368534
ABSTRACT:
The present invention relates to an isolated mimetic of functional myostatin comprising part of the amino acid sequence of functional myostatin, such that the mimetic is capable of inhibiting muscle growth.
REFERENCES:
patent: WO 98/33887 (1998-08-01), None
patent: WO 99/06559 (1999-02-01), None
patent: WO 99/40181 (1999-08-01), None
patent: WO 99/42573 (1999-08-01), None
Verma et al. (1997, Nature, vol. 389, pp. 239-242).
Anderson et al.(1998, Nature, vol. 392, pp. 25-30).
Palu et al.(1999, Journal of Biotechnology, vol. 68, pp. 1-13).
Sigmund, C.D. 2000. Arterioscler Thromb Vasc Biol.20:1425-1429.
Wall, R.J. 1996. Theriogenology 45:57-68.
Jacks et al. (1992) Nature vol. 359, pp. 295-300.
Chorev, M. et al., 1993 “A Dozen Years of Retro-Inverso Peptidomimetics”Acc. Chem. Res., 26:266-273.
Freidinger, R.M et al., 1982 “Protected Lactam-Bridged Dipeptides for Use as Conformational Constraints in Peptides”J. Org. Chem., 47:104-109.
Gonzales-Cadavid N.F. et al., 1998 “Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting”PNAS USA95:14938-14943.
Grobet L., et al., 1997 “A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle”Nature Genetics17:71-74.
Gyuris J., et al., 1993 “Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2”Cell75:791-803.
Hogan, J.C. Jr., 1997 “Combinatorial chemistry in drug discovery”Nature Biotechnology, 15:328-330.
Ji S., et al., 1998 “Myostatin expression in porcine tissues: tissue specificity and developmental and postnatal regulation”Am. J Physiol. 275:R1265-R1273.
Kambadur R., et al., 1997 “Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle”Genome Res7:910.
L'Huillier P.J., et al., 1996 “Efficient and specific ribozyme-mediated reduction of bovine α-lactalbumin expression in double transgenic mice”PNAS USA93:6698-6703.
McPherron A.C. & Lee S.J. 1997 “Double muscling in cattle due to mutations in the myostatin gene”PNAS USA94:12457-12461.
McPherron A.C. et al., 1997 “Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member”Nature387:83-90.
Nagai, U. et al., 1985 “Synthesis of a Bicyclic Dipeptide with the Sahpe of β-Turn Central Part”Tetrahedron Letters26: 647-650.
Olson et al., 1993 “Concepts and Progress in the Development of Peptide Mimetics”J. Med. Chem., 36:3039-3049.
Sharma M., et al., 1999 Myostatin, a transforming growth factor-β superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct.J Cell Physiol180:1-9.
Smythe, M.L., et al., 1994 “Design and Synthesis of a Biologically Active Antibody Mimic Based on an Antibody-Antigen Crystal Structure”Am. Chem. Soc. 116:2725-2733.
Bass James Johnston
Berry Carole J.
Kambadur Ravi
Sharma Mridula
Thomas Mark F.
Knobbe Martens Olson & Bear LLP
Orico Limited
Qian Celine
LandOfFree
Myostatin and mimetics thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Myostatin and mimetics thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Myostatin and mimetics thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2815355