Myocardial protection during ischemia and reperfusion

Details Myocardial protection during ischemia and reperfusion Myocardial protection during ischemia and reperfusion

1994-09-09

1996-12-03

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514211, A61K 3155

Patent

active

055808670

ABSTRACT:
Myocardial protection is achieved by administering to a patient an effective amount of a benzothiazepine derivative. The benzothiazepine derivatives have the following general chemical formula: ##STR1## wherein R.sub.1 represents hydrogen or methyl,

REFERENCES:
patent: 4520112 (1985-05-01), Snyder et al.
patent: 4743599 (1988-05-01), Muller
patent: 4902684 (1990-02-01), Floyd
patent: 4950663 (1990-08-01), Dumont et al.
Nagao Chem Pharm. Bull 21 1, p. 92 (1973) Abst.
Tanguay J Cardiovasc. Pharmacol. 24 #6 p. 950, 1994 Abs.
Multicenter Diltiazem Postinfarction Trial Research Group, New Eng. J. Med., 319:385-92 (1988).
Grover et al., J. Pharmacology and Exp. Therapeutics, 246:263-69 (1988).
Moss et al., Circulation, Supp IV, 80:102-06 (1989).
Grover et al., J. Cardiovascular Pharmocol., 16:219-27 (1990).
Rousseau et al., Cardiovascular Research, vol. XXV, No. 4, pp. 319-329 (1991).
Goldstein et al., Circulation 83:52-60 (1991).
Poole-Wilson, Am. J. Cardiology, 75:4E-9E (1995).
Tanguay et al., J. Cardiovascular Pharmacol., 24:950-59 (1994).
Kiyomoto et al., Circ. Res., 52 (Supp I): 115-19 (1983).
Nasa et al., J. Pharmacol. and Exp. Therapeutics, 255 (2):680-89 (1990).
Bourassa et al., Chest, 78:1 (Supp) pp. 224-30 (Jul. 1980).
Rovelli et al., Lancet, Feb. 22, 1986, pp. 397-401.
Reimer et al., Circulation, 56 (5):786-94 (1977).
Braunwald et al., J. Clin. Invest., 76:1713-19 (1985).
Schofer et al., JACC, 5 (3):593-98 (1985).
Lorgeril et al., Am. J. Cardiovascular Pathology, 3 (2):143-54 (1990).
Rousseau et al., J. Cardiovascular Pharmacol., 22:264-72 (1993).
Rousseau et al., J. Pharmacol. and Exp. Therapeutics, 268 (3):1252-60 (1994).
Roberts, Circulation, (Supp IV) 80 (6) IV:93-101 (1989).
Messerli et al., Am. J. Cardiology, 72:818-20 (1993).
Schwartz et al., J. Org. Chem., 57:851-56 (1992).
Rousseau et al., Am. Heart J., 125 (6):1553-63 (1993).
Li et al., J. Med. Chem., 35:3246-53 (1992).
Product sheet for "Cardizem SR", Medicine North America, 36 p. 6558 (1989).
Merck Index, Entry 3189 "Diltiazem", 10th Ed. (1983).

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