Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1998-03-31
Ketter, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4351723, 435354, 435377, C12Q 168, C12N 510
Patent
active
057337276
ABSTRACT:
Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the heart.
REFERENCES:
Development, vol. 110, issued 1990, Y. Lallemand et al., "An in situ Assessment of the Routes and Extents of Colonisation of the Mouse Embryonic Stem Cells and their Descendants", pp. 1241-1248, see entire document.
DNA, vol. 5, No. 5, issued 1986, R.J. MacDonald et al., "Transgenic Progeny Inherit Tissue-Specific Expression of Rat Elastase I Genes", pp. 393-401, see entire document.
Science, vol. 254, issued 1991, Dhawan et al., "Systemic Delivery of Human Growth Hormone by Injection of Genetically Engineered Myoblasts", pp. 1509-1512.
The New Biologist, vol. 3, No. 1, issued Jan. 1991, Acsadi et al., "Direct Gene Transfer and Expression into Rat Heart in Vivo", pp. 71-81.
Canadian Journal of Physiology, vol. 61, issued 1983, S.L. Jacobson et al., "Evidence for Functional Sodium and Calcium Ion Channels in the Membrane of Cultured Cardiomyocytes of the Adult Rat", pp. 1312-1316, see entire document.
Steinhelper, M.E., Cochrane, K.L. and Field, L.J., "Hypotension In Transgenic Mice Expressing Atrial Natriuretic Factor Fusion Genes", Hypertension, vol. 16, No. 3, pp. 301-307, (1990).
Brummer, A.M. et al., "Site-Directed Mutagenesis Of Cysteine Residues In The Pro Region Of The Transforming Growth Factor beta 1 Precursor. Expression And Characterization Of Mutant Proteins," J.Biol.Chem., 264(23):13660-13664 (1989).
Delcarpio, J.B., Lanson, N.A., Jr., Field, L.J. and Claycomb, W., "Morphological Characterization Of Cardiomyocytes Isolated From A Transplantable Cardiac Tumor Derived From Transgenic Mouse Atria (AT-1 cells)," Cir.Rsrch., 69:1591-1600 (1991).
Fields, L.J., "Artrial Natriuretic Factor-SV40 T Antigen Transgenes Produce Tumors and Cardiac Arrhythmias In Mice," Science, 239:1029-1033 (1988).
Gussoni, E., Pavlath, G.K., Lanctot, A.M., Sharma, K.R., Miller, R.G., Steinman, L. and Blau, H.M., "Normal Dystrophin Transcripts Detected In Duchenne Muscular Dystrophy Patients After Myoblast Tansplantation," Nature, 356:435-438 (1992).
Janse, M.J., Cinca, J., Morena, H., Fiolet, J.W., Kleber, A.G., deVries, G.P., Becker, A.E. and Durrer, D., "The Border Zone In Myocardial Ischemia. An Electrophysiological, Metabolic And Histochemical Correlation In the Pig Heart," Circulation Research, 44:576-588 (1979).
Jiao, S., Gurevich, V. and Wolff, J.A., "Long-Term Correction Of Rat Model Of Parkinson's Disease By Gene Therapy", Nature, vol. 362, pp. 450-453 (1993).
Katz, E., Steinhelper, M.E., Daud, A., Delcarpio, J.B., Claycomb W.C. and Field, L.J., "Cardiomyocyte Proliferation In Mice Expressing a-Cardiac Myhosin Heavy Chain-SV40 T-Antigen Transgenes," Amer.J.Phys., 262 (Heart and Circulatory Physiology 31): H1867-1876 (1992).
Koh, G.Y., Soonpaa, M.H., Klug, M.G. and Field, L.J., "Long-Term Survival Of AT-1 Cardiomyocyte Grafts In Syngeneic Myocardium," Amer.Physiol.Soc., pp. H1727-H1733 (1993).
Koh, G.Y., Klug, M.G., Soonpaa, M.H., and Field, L.J., "Differentiation and Long-Term Survival of C2C12 Myoblast Grafts In Heart," J.Clin.Invest., vol. 92, Sep. 1993.
Loewy, A.D., Bridgman, P.C. and Mettenleiter, T.C., "b-Galactosidase Expressing Recombinant Pseudorabies Virus For Light and Electron Microscopic Study Of Transneuronally Labeled CNS Neurons," Brain Research, 555:346 (1991).
Nadal-Ginard, B., "Commitment, Fusion, And Biochemical Differentiation Of A Myogenic Cell Line In the Absence of DNA Synthesis," Cell, 15:885-864 (1978).
Rockman, H.A., Ross, R.A., Harris, A.N., Knowlton, K.U., Steinhelper, M.E., Field, L.J., Ross, J., Jr. and Chien, K.R., "Segregation Of Atrial-Specific And Inducible Expression Of An ANF Transgene In An in vivo Murine Model of Cardiac Hypertrophy" Proc.Natl.Acad.Sci., USA, 88:8277-8281 (1991).
Samuel, S.K. et al. "Autocrine Induction Of Tumor Protease Production And Invation By A Metallothionein-Regulated TGF-beta 1 (Ser223,225)," EMBO Journal (JC:emb), 11(4):1599-1605 (1992).
Spear, J.F., Michelson, E.L., and More, E.N., "Cellular Electrophysiologic Characteristics Of Chronically Infarcted Myocardium In Dogs Susceptible To Sustained Ventricular Tachyarrhythmias," J.of the Amer.College of Cardiology 4:1099-1110 (1983).
Steinhelper, M.E. and Field, L.J., "Cardiac Tumors And Dysrhythmias In Transgenic Mice," Toxicologic Pathology 18:464-469 (1990).
Steinhelper, M.E., Lanson, N., Dresdner, K., Delcarpio, J.B., Wit, A., Claycomb, W.C. and Field, L.J., "Proliferation In Vivo And In Culture Of Differentiated Adult Atrial Cardiomyocytes From Transgenic Mice", Amer.J.Phys., 259 (Heart and Circulatory Physiology 28) H1826-H1834 (1990).
Thompson, L., "Fetal Transplants Show Promise", Science, 257:868-870 (1992).
Yaffe, D., and O. Saxel, "Serial Passaging And Differentiation Of Myogenic Cells Isolated From Dystrophic Mouse Muscle," Nature, 270:725-727 (1977).
Shen et al., Int. J. Dev. Biol., vol. 36, 1992, pp. 465-476.
Kitsis et al., PNAS, vol. 88, pp. 4138-4142.
Indiana University Foundation
Ketter James
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