Myeloperoxidase detection in diagnosis and prognosis of...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007200, C435S007910, C435S007920

Reexamination Certificate

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07569353

ABSTRACT:
The present invention relates to the diagnosis of hematopoietic disorders and to determining the prognosis of patients affected by such disorders. The methods generally comprise determining a level of myeloperoxidase in a body fluid sample from the individual and using the level as a factor for diagnosing the disorder in the mammal or as a factor for determining the prognosis of a patient diagnosed with such a disorder. Myelodysplastic syndrome, acute myeloid leukemia and chronic myeloid leukemia are exemplary disorders. Also provided are method of cancer therapy involving reducing the level of myeloperoxidase in the body fluid of the individual.

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Giles et. al., A prognostic model for survival in chronic lymphocytic leukemia based on p53 expression. British Journal of Hemotology, 121:578-585.
Kamik et al., Use of polyclonal anti-myeloperoxidase antibody in myeloid lineage determination. Indian J Med Res. 100: 272-6, Dec. 1994.
Matsuo et al., The percentage of myeloperoxidase-positive blast cells is a strong independent prognostic factor in acute myeloid leukemia, even in the patients with normal karyotype. Leukemia, 17:1538-1543, 2003.

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