Myelomas for producing human/human hybridomas

Details Myelomas for producing human/human hybridomas Myelomas for producing human/human hybridomas

1985-02-14

1988-01-19

Tarcza, John E.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4351722, 435948, 43524027, 935100, C12N 500, C12N 1500, C12R 191

Patent

active

047204591

ABSTRACT:
Human myeloma fusing lines and human/human hybridomas produced therefrom are disclosed. In one embodiment, the myeloma cell line is HAT sensitive, does not secrete detectable levels of Epstein-Barr virus EBNA-I protein, and does not secrete or elaborate detectable levels of myeloma immunoglobulin. The myeloma cell line and resulting hybridoma are stable over time, and thus permit production of commercial quantities of human monoclonal antibody.

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