Myeloid cell specific promoter

Details Myeloid cell specific promoter Myeloid cell specific promoter

1993-04-14

1996-03-26

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4352402, 4353201, C07H 2104, C12N 516, C12N 1585

Patent

active

055021760

ABSTRACT:
The subject application is drawn to a method of transfecting a myeloid cell line and a method of producing a selected product in a myeloid cell. The invention also includes myeloid cell specific promoters and enhancers, and constructs which contain these promoters and enhancers. The invention further includes a myeloid cell specific promoter-heterologous gene construct, where the expression of the heterologous gene is under the control of the myeloid cell specific promoter. The invention also includes a transgenic non-human mammal in which myeloid cells express a protein encoded by a heterologous gene. Finally the invention includes a method for identifying factors that can regulate myeloid cell specific transcription.

REFERENCES:
Fregien et al., GENE 48:1-11 (1986).
Morishita et al., J. Biol. Chem. 262(31):15206-15213 (Nov. 5, 1987).
Pahl, Heike L. et al., "Optimization of Transient Transfection into Human Myeloid Cell Lines Using a Luciferase Reporter Gene", Exp. Hematol. 19:1038-1041 (1991).
Arnaout, M. Amin et al., "Amino Acid Sequence of the Alpha Subunit of Human Leukocyte Adhesion Receptor Mol (Complement Receptor Type 3)," J. of Cell Biology 106:2153-2158 (1988).
Shelley, C. Simon et al., "The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression," Proc. Natl. Acad. Sci. USA 88:10525-10529.
Pahl, H. L. et al., "Characterization of the Myeloid-Specific CD11b Promoter," Blood 79(4):865-870 (1992).
Pahl, H. L. et al., "The CD11B Promoter Directs Monocytic expression fo a Reporter Gene in Transgenic Mice," The American Society of Hematology, 33rd Annual Meeting, ASH Abstract (1991).

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