Mycoplasma subunit vaccine

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

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C424S184100, C424S185100, C424S203100, C435S041000, C530S350000

Reexamination Certificate

active

07833536

ABSTRACT:
The present invention relates i.a. to vaccines for combatingMycoplasmainfection, to mycoplasmal L-α-glycerophosphate oxidase for use in such vaccines, to the use of mycoplasmal L-α-glycerophosphate oxidase for the manufacturing of such vaccines, to methods for the preparation of such vaccines and to diagnostic tests for the discrimination of animals vaccinated with said vaccines and animals vaccinated with whole cell vaccines or animals suffering from field infection.

REFERENCES:
patent: 2002089838 (2002-11-01), None
patent: WO 02/089838 (2002-11-01), None
patent: 2004101795 (2004-11-01), None
Vilei et al, Mycoplasmal infections:Molecular analysis of virulence attributes of bovine Mycoplasma species, Institute of Veterinary Bacteriology, University of Bern, Annual Report 2003, pp. 1-7 and 12-14 only.
Greenspan et al. (Nature Biotechnology 7: 936-937, 1999).
Bowie et al (Science, 1990, 257:1306-1310).
Ellis (Vaccines, W.B. Saunders Company, 1988, Chapter 29).
Boslego et al (Vaccines and Immunotherapy, Pergaman Press, 1991, Chapter 17).
Fernald et al (Infection and Immunity, Jun. 1970, vol. 1, No. 6, p. 559-565).
Brennan, P.C. et al. (Jun. 1969). Relationship of Hydrogen Peroxide Production by Mycoplasma pulmonis to Virulence for Catalase Deficient Mice. Journal of Bacteriology. 98(3):1036-1040.
Pilo, P. et al. (Oct. 2005). A Metabolic Enzyme as a Primary Virulence Factor of Mycoplasma mycoides subsp. mycoides Small Colony. Journal of Bacteriology. 187(19):6824-6831.
Thiaucourt, F. et al. (2003). Contagious Bovine Pleuropneumonia Vaccines, Historic Highlights, Present Situation and Hopes. Developments in Biologicals. 114:147-160.
Djordjevic, S.P. et al. (2003). Characterization of a chromosomal region of Mycoplasma sp. bovine group 7 strain PG50 encoding a glycerol transport locus (gtsABC). Microbiology. 149:195-204.
Houshaymi, B.M. et al. (Feb. 1997). Oxidation of glycerol differentiates African from European isolates of Mycoplasma mycoides subspecies mycoides SC (small colony). The Veterinary Record. 140(7):182-183.
Vilei, E.M. et al. (Jan. 2001). Genetic and Biochemical Characterization of Glycerol Uptake in Mycoplasma mycoides subsp. mycoides SC: Its Impact on H2O2 Production and Virulence. Clinical and Diagnostic Laboratory Immunology. 8(1):85-92.
Westberg, J. et al. (2004). The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP). Genome Research. 14(2):221-227.

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