Mycoplasma hyopneumoniae bacterin vaccine

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Combination of viral and bacterial antigens

Reexamination Certificate

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C424S202100, C424S203100, C424S184100, C424S234100, C424S264100, C424S220100, C424S204100, C424S211100, C424S221100, C424S206100, C424S209100, C424S093100, C424S093400

Reexamination Certificate

active

11318983

ABSTRACT:
The invention provides an improvedMycoplasma hyopneumoniaebacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivatedMycoplasma hyopneumoniaebacterin and an adjuvant mixture, which, in combination, provide immunity fromMycoplasma hyopneumoniaeinfection after a single administration, and elicit an immune response specific toMycoplasma hyopneumoniaebacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably CARBOPOL®, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polyoxypropylene block copolymer such as PLURONIC®. The vaccine composition may optionally include a preservative, preferably thimerosol and/or EDTA. In another embodiment, the invention provides an improvedMycoplasma hyopneumoniaebacterin vaccine composition, which advantageously provides immunity from infection after a single administration, and comprises an inactivatedMycoplasma hyopneumoniaebacterin and an adjuvant or adjuvant mixture, which, in combination, provide immunity fromMycoplasma hyopneumoniaeinfection after a single administration, and elicit an immune response specific toMycoplasma hyopneumoniaebacterin and including cell-mediated immunity and local (secretory IgA) immunity, in combination with other vaccine components.

REFERENCES:
patent: 6632439 (2003-10-01), Liem et al.
patent: 0 315 153 (1989-05-01), None
patent: WO 91/18627 (1991-12-01), None
patent: WO 92/03157 (1992-03-01), None
patent: WO 95/30437 (1995-11-01), None
Allison, A. C., “Squalene and Squalane Emulsions as Adjuvants,” Methods 19:87-93, 1999.
Goodwin et al., “Enzootic Pneumonia of Pigs: Immunization Attempts InoculatingMycoplasma suipneumoniaeAntigen by Various Routes and with Different Adjuvants,” British Vet. J. 129(5):456-464, Sep.-Oct. 1973.
Byars et al., “Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity,” Vaccine, 5:223-228, Sep. 1987.

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