Mycobacterium strains with modified erp gene and vaccine...

Details Mycobacterium strains with modified erp gene and vaccine... Mycobacterium strains with modified erp gene and vaccine...

2007-01-09

2007-01-09

Swartz, Rodney P (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

C424S009100, C424S009200, C424S130100, C424S150100, C424S164100, C424S184100, C424S185100, C424S248100, C530S300000, C530S350000, C536S023100, C536S023700

Reexamination Certificate

active

10259460

ABSTRACT:
Mycobacteriumstrains in which the erp gene is modified, and vaccine compositions comprising suchMycobacteriumstrains are provided. The modification of the erp gene may decrease the virulence and the persistence of theMycobacteriumstrains.

REFERENCES:
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patent: 6248581 (2001-06-01), Gicquel et al.
Berthet et al, “Attenuation of Virulence by Disruption of theMycobacterium tuberculosis erpGene,”Science, Oct. 23, 1998, vol. 282, pp. 759-762.
V. Pelicic et al., “Positive Selection of Allelic Exchange Mutants inMycobacterium bovisBCG”, FEMS Microbiology Letters, vol. 144, pp. 161-166, (1996).
F-X Berthet et al., “Characterization of theMycobacterium tuberculosis erpGene Encoding a Potential Cell Surface Protein with Repetitive Structures”, Microbiology, vol. 141, No. 9, pp. 2123-2130, (1995).
E.M. Lim et al., “Identification ofMycobacterium tuberculosisDNA Sequences Encloding Exported Proteins by Using phoA Gene Fusions”, Journal of Bacteriology, vol. 177, No. 1, pp. 59-65, (1995).
V. Pelicic et al., “Efficient Allelic Exchange and Transposon Mutagenesis inMycobacterium tuberculosis” Proc. Natl. Acad. Sci., vol. 94, pp. 10955-10960, (1997).

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