Mycobacterium proteins and applications

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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530350, 4242001, 4242031, 4242481, G01N 33554

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active

060602597

ABSTRACT:
Mycobacterium proteins, in particular those of M. bovis, having molecular weights between approximately 44.5 and 47.5 kD. These proteins can have molecular weights of approximately 45 kD or 47 kD and isoelectric pH of approximately 3.7 (45 and 47 kD proteins) and 3.9 (47 kD proteins).
These proteins or hybrid proteins containing a part of their sequences can be used as vaccines or as drugs, or for the detection and monitoring of tuberculosis in particular in man and in cattle.

REFERENCES:
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Miura et al, "Comparative Studies with Various Substrains of Mycobacterium Bovis BCG on the Production of an Antigenic Protein, MPB70", Infection and Immunity, vol. 39, (1983), pp. 540-545.
Abou-Zeid et al, "Characterization of the Secreted Antigens of Mycobacterium Bovis BCG: Comparison of the 46-Kilodalton Dimeric Protein with Proteins MPB64 and MPB70", Infection and Immunity, vol. 55, (1987), pp 3213-324.

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