Mycobacterium phlei mutants convert sterols to androsta-1,4-dien

Details Mycobacterium phlei mutants convert sterols to androsta-1,4-dien Mycobacterium phlei mutants convert sterols to androsta-1,4-dien

1980-09-08

1982-08-17

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a...

435863, C12P 3316

Patent

active

043450296

ABSTRACT:
Mutants which are used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione (AD). ADD and AD are valuable intermediates to make useful steroids.

REFERENCES:
patent: 3388042 (1968-06-01), Arima et al.
patent: 3684656 (1972-08-01), van de Waard et al.
Mamoli et al., Ber. 70, 470, 471 and 2079-2082, (1937).

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