Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1995-07-27
1996-12-10
Elliott, George C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 791, 435 8, 4351721, 4351723, 4353201, 536 2372, C12Q 170, C12Q 168, C12Q 116, C12N 1533
Patent
active
055829694
ABSTRACT:
Mycobacteriophage DS6A has been characterized and found to specifically infect all species of the TB complex, without any detectable infection of mycobacteria species other than those of the TB complex. DNA sequence analysis revealed several potential open reading frames, including one encoding a protein analogous to gp37 of mycobacteriophage L5 and a second encoding a protein with significant homology to the S. coelicolor DNA polymerase .beta. subunit. Based on the DNA sequence analysis, cloning sites can be identified for insertion of reporter genes, making DS6A useful as a reporter phage for specific detection and identification of species of the TB complex.
REFERENCES:
Bates, in Tuberculosis Current Concepts and Treatment L. N. Friedman Ed., CRC Press pp. 81-92 (1994) "Chapter 5, New Diagnostic Methods".
Jacobs et al. Science 260 819-822 (1993) Rapid assessment of drug susceptabilities of Mycobacterium . . . .
Kotilainen, et al. J. of Bacteriology 175 3089-3095 (1993) Binding of an Escherichia coli double stranded DNA virus PRD1 . . .
Becker et al. Biochimica et Biophysica Acta 264 165-170 (1972) Inactivation by avidin of biotin-modified bacteriophage.
Beyer, Jr. Wayne F.
Dickson Julie A.
Hamilton Paul T.
Little Michael C.
Pearson Robert E.
Becton Dickinson and Company
Brusca John S.
Elliott George C.
Fugit Donna R.
LandOfFree
Mycobacteriophage specific for the mycobacterium tuberculosis co does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mycobacteriophage specific for the mycobacterium tuberculosis co, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mycobacteriophage specific for the mycobacterium tuberculosis co will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-423123