Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2005-12-13
2005-12-13
Swartz, Rodney P (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S009100, C424S009200, C424S130100, C424S164100, C424S168100, C424S180100, C424S200100, C424S234100, C435S004000, C435S007100, C435S007400, C435S015000, C435S029000, C435S183000, C435S440000, C435S471000
Reexamination Certificate
active
06974580
ABSTRACT:
Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting growth and/or virulence of a pathogenic mycobacterium, and methods of treating disease conditions associated with a pathogenic mycobacterium, particularly by administering an inhibitor of a mycobacterial sulfation pathway protein. The present invention further provides genetically modified mycobacteria having a defect in a sulfation pathway enzyme gene; and immunogenic compositions that include such genetically modified mycobacteria.
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Bertozzi Carolyn R.
Mougous Joseph D.
Williams Spencer J.
Borden Paula A.
Bozicevic Field & Francis LLP
Swartz Rodney P
The Regents of the University of California
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