Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1992-12-18
1995-12-26
Woodward, Michael P.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
436503, 4241901, 4242481, 530326, 530327, G01N 3350, G01N 33569, A61K 3804, A61K 3904
Patent
active
054787262
ABSTRACT:
Recombinant 540 amino acid residue and 517 amino acid residue proteins encoded by the genome of Mycobacterium tuberculosis are disclosed as are vectors for propagating their DNA sequences and expressing the proteins. Also disclosed are methods for using those proteins. Peptides that correspond substantially to the sequences of those proteins and methods of their use are also disclosed, as are polymers containing peptide repeating units corresponding to the 540 residue protein and also polymers containing 517 protein pentapeptides as repeating units.
REFERENCES:
patent: 4769237 (1988-09-01), Bittle et al.
patent: 4906742 (1990-03-01), Young et al.
Atassi et al., "Chap 1: A Comparison of T Cell and B Cell Recognition of Defined Protein Antigens", in Antigen-Specific T Cell Receptors and Factors, ed. J. J. Marchalonis, pp. 37-51+55-63 (1987).
Sela, Adv. Immunol., vol. 5, pp. 115-117 (1966).
Current Communications in Molecular Biology, Immune Recognition of Protein Antigens, Laver et al., eds., Cold Spring Harbor Lab., N.Y. pp. 71-76; 156-160.
Francis et al., Vaccines 88, Ginsberg et al., eds., Cold Spring Harbor Lab., N.Y. (1988) pp. 1-7.
Francis et al., Vaccines 87, Chanock et al., Eds., Cold Spring Harbor Lab., N.Y. (1987) pp. 60-67.
Germain, R. N., "The Ins and Outs of Antigen Processing and Presentation," Nature 322:687-689 (1986).
Schwartz, R. H., "Fugue in T-Lymphocyte Recognition", Nature 326:738-739 (1987).
Young et al., "Dissection of Mycobacterium tuberculosis antigens using recombinant DNA", Proc. Natl. Acad. Sci. 82:2583-2587 (1985).
Spouge et al., "Strong conformational propensities enhance T cell antigenicity," J. Immunol 138:204-212 (1987).
Berzofsky, J. A., "Intrinsic and extrinsic factors in protein antigenic structure," Science 229:932-940 (1985).
DeLisi et al., "T-cell antigenic sites tend to be amphipathic structures," Proc. Natl. Acad. Sci. 82:7048-7052 (1985).
Fatham et al., Ann. Rev. Immunol., 1:633-655 (1985).
Portions of computer-assisted search, File 154:Medline.
General Index p. 392, title and copyright pages of the ATCC catalogue of Cell Lines and Hybridomes for 1988.
Bittle et al., Nature, 298:30-33 (Jul., 1982).
Finnegan et al., "The T cell repertoire for recognition of a phylogenetically distant . . . ," J. Exp. Med. 164:897-910 (1986).
Shinnick et al., Infect. Immun., 55:1932-1935 (Aug., 1987).
Gillis et al., Infect. Immun., 37:172-178 (1982).
Gillis et al., Infect. Immun., 49:371-377 (1985).
Mustafa et al., Lepr. Rev., 57, Suppl. 2:123-130 (1986).
Thole et al., Infect. Immun., 50:800-806 (1985).
Emmerich et al., J. Exp. Med., 163:1024-1029 (1986).
Mehra et al., Proc. Natl. Acad. Sci. USA, 83:7013-7017 (1986).
Engers (Rapporteur), Infect. Immun., 51:718-720 (1986).
Young et al., Nature, 316:450-452 (1985).
Mustafa et al., Nature, 319:63-66 (1986).
Boom et al., Infect. Immun., 55:2223-2229 (Sep. 1987).
Kaufmann et al., Eur. J. Immunol., 17:351-357 (1987).
Melancon-Kaplan et al., Proc. Natl. Acad. Sci., USA, 85:1917-1921 (Mar. 1988).
Lu et al., Infect. Immun., 55:2378-2382 (Oct. 1987).
Kingston et al., Infect. Immun., 55:3149-3154 (Dec. 1987).
Oftung et al., J. Immunol., 141:2749-2754 (1988).
Houghten Richard
Shinnick Thomas
The Scripps Research Institute
Woodward Michael P.
LandOfFree
Mycobacterial recombinants and peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mycobacterial recombinants and peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mycobacterial recombinants and peptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1368589